Microfluidics

Our research in microfluidics aims at developing lab-on-a-chips, i.e. performing chemical or biological processing at small-scale. Our activity is organised around the miniaturization of physico-chemical unit operations, such as liquid/liquid separation by membrane pervaporation [1,6], continuous flow crystallisation [2,12,13] and bubble dissolution in bubbly flow regime [3,4,10]. Integrating one or several of these unit operations should lead to innovative and competing lab-on-a-chip devices for the fields of fine chemistry, pharmaceuticals and biotechnology.

Bubbles and droplets are elementary components in microfluidics and deserved a special attention as they are widely used in two-phase microfluidic applications. Therefore, modelling and predicting their dynamics in microchannels is of utmost importance. We therefore investigate on the one hand the dynamics of confined (Taylor) bubbles, and especially the influence of buoyancy [7] and dewetting [8] on the lubrication film. And on the other hand, we study the dynamics of unconfined bubbles in microchannels, paying a special attention to the inertial and capillary migration forces [9], as well as to the role of surfactants [11].

Applications to life sciences are also investigated such as cell/cell adhesion in micro channels [5], micro beads fabrication for protein purification, micro encapsulation of proteins or single-bacterium analysis and sorting [ongoing researches]

  • Bubble dissolution
    • Bubble dissolution

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  • Bubbles and surfactants
    • Bubbles and surfactants

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  • Protein encapsulation
    • Protein encapsulation

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[13] Rimez B., Conté J., Norrant E., Cognet P., Gourdon C. & Scheid B., Continuous-Flow Tubular Crystallization to Discriminate between Two Competing Crystal Polymorphs. Part II: anti solvent crystallisation, Crystal Growth & Design 18, 6440–6447
[12] Rimez B., Debuysschère R., Conté J., Norrant E., Cognet P., Gourdon C. & Scheid B., Continuous-Flow Tubular Crystallization to Discriminate between Two Competing Crystal Polymorphs. Part I: cooling crystallisation, Crystal Growth & Design 18, 6431–6439
[11] Atasi O., Haut B., Pedrono A., Scheid B. & Legendre D., A numerical analysis of the influence of surfactants and deformation on the dynamics of a centered bubble in a circular microchannel, Langmuir 34, 10048-10062
[10] Rivero-Rodriguez J. & Scheid B., Bubbles dissolution in cylindrical microchannels, Submitted to Journal of Fluid Mechanics
[9] Rivero-Rodriguez J. & Scheid B., Bubble dynamics in microchannels: inertial and capillary migration forces, Journal of Fluid Mechanics 842, 215-247 (2018)
[8] khodaparast S., Atasi O., Debris A., Scheid B. & Stone H.A., Dewetting of thin liquid films surrounding air bubbles in microchannels, Langmuir 34, 1363-1370 (2018)
[7] Atasi O., Khodaparast S., Scheid B. & Stone H.A., Effect of buoyancy on the motion of a long bubble in a horizontal tube, Physical Review Fluids 2, 094304 (2017)
[6] Ziemecka I., Haut B. & Scheid B., Continuous separation, with microfluidics, of the components of a ternary mixture: from vacuum to purge gas pervaporation, Microfluidics & Nanofluidics 21, 84 (2017)
[5] Petit A.-E., Demotte N., Scheid B., Wildmann C., Bigirimana R., Gordon-Alonso M., Carrasco J., Valitutti S., Godelaine D. & van der Bruggen P., A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion, Nature Communications 712242 (2016)
[4] Mikaelian D., Haut B. & Scheid B., Bubbly flow and gas-liquid mass transfer in square and circular microchannels for stress-free and rigid interfaces: dissolution model, Microfluidics & Nanofluidics 19, 899-911 (2015)
[3] Mikaelian D., Haut B. & Scheid B., Bubbly flow and gas-liquid mass transfer in square and circular microchannels for stress-free and rigid interfaces: CFD analysis, Microfluidics & Nanofluidics 19, 523-545 (2015)
[2] Rimez B., Haut B. & Scheid B., Development of a continuous “self-seeding” microfluidic crystallization device for active pharmaceutical ingredients, BIWIC 2014 conference, Rouen (France) (2015)
[1] Ziemecka, I., Haut B. & Scheid B., Hydrogen peroxide concentration by pervaporation of a ternary liquid solution in microfluidicsLab on a chip 15, 504 (2015)