IMG_0589

Microfluidics

Our research in microfluidics aims at developing lab-on-a-chips, i.e. performing chemical engineering processing at small-scale. Our activity is therefore organized around the miniaturization of physico-chemical unit operations, such as liquid/liquid separation by membrane pervaporation [1,6], heterogeneous catalytic reaction in microchannels, droplet-based crystallization [2] and liquid/gas absorption in bubbly flow regime [3,4]. Integrating one or several of these unit operations should lead to innovative and competing lab-on-a-chip devices for the fields of fine chemistry, pharmaceuticals and biotechnology.

Applications to life sciences are also investigated such as cell/cell adhesion in micro channels [5], micro beads fabrication for protein purification, or micro encapsulation of proteins.

  • Bubble dissolution
    • Bubble dissolution

    • Watch Video

  • Bubbles and surfactants
    • Bubbles and surfactants

    • Watch Video

  • Protein encapsulation
    • Protein encapsulation

    • Watch Video

[6] Ziemecka I., Haut B. & Scheid B., Continuous separation, with microfluidics, of the components of a ternary mixture: from vacuum to purge gas pervaporation, Microfluidics & Nanofluidics 21, 84 (2017)
[5] Petit A.-E., Demotte N., Scheid B., Wildmann C., Bigirimana R., Gordon-Alonso M., Carrasco J., Valitutti S., Godelaine D. & van der Bruggen P., A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion, Nature Communications 712242 (2016)
[4] Mikaelian D., Haut B. & Scheid B., Bubbly flow and gas-liquid mass transfer in square and circular microchannels for stress-free and rigid interfaces: dissolution model, Microfluidics & Nanofluidics 19, 899-911 (2015)
[3] Mikaelian D., Haut B. & Scheid B., Bubbly flow and gas-liquid mass transfer in square and circular microchannels for stress-free and rigid interfaces: CFD analysis, Microfluidics & Nanofluidics 19, 523-545 (2015)
[2] Rimez B., Haut B. & Scheid B., Development of a continuous “self-seeding” microfluidic crystallization device for active pharmaceutical ingredients, BIWIC 2014 conference, Rouen (France) (2015)
[1] Ziemecka, I., Haut B. & Scheid B., Hydrogen peroxide concentration by pervaporation of a ternary liquid solution in microfluidicsLab on a chip 15, 504 (2015)